Biosynth Carbosynth products are widely used by scientific community and cited in peer-reviewed, high impact journals on a daily basis. We highlight 3 top publications every month but you can find a full list of papers citing our molecules here.
Inhibition of a specific cellular protease by camostat mesylate results in lower SARS-CoV-2 infectivity
The chemiluminescence-based enzyme substrates are promising candidates for new generation diagnostics.
Scleroglucan is a promising agent with the potential to alleviate extensive thirst in patients with swallowing disorder.
6'-sialylgalactose was efficient in inhibiting new vessel formation in tumours as well in a model of retinopathy.
This research was co-developed by prof. Spingler from the University of Zürich and scientists from Biosynth Carbosynth.
The effects of the bean extract were comparable to reference drugs metformin and atorvastatin.
(S)-fluoxetine enantiomer inhibits replication of enteroviruses by binding to the non-structural protein 2C.
Lewis antigens and H blood group antigens were used to characterize two bacterial α-fucosidases.
The structure of BKV in complex with GT1b (OO16323) will aid in developing new therapies.
Viral polymerase inhibitor 7-deaza-2’-C-methyladenosine reduces the load of viral RNA and infectious virus in mice testicles.
6’-sialyllactose and 3’-sialyllactose regulate functioning of intestinal epithelium.
Prebiotic and human milk oligosaccharides ameliorate rotavirus-induced diarrhea in animal models.
X-glucuronide was used for the visualisation of expression of the reporter enzyme ß-glucuronidase (GUS).
CMP-sialic acid was used to study mechanisms of substrate selectivity of CMP-sialic acid transproter.
AVR-25 binds to TLR4 and induces anti-inflammatory cytokine IL-10, reducing organ damage and mortality
This method will help to understand therapeutic resistance in patients treated with these compounds
This novel LC-MS/MS-based method can be beneficial for future pre-clinical and clinical studies
A range of substrates for carbohydrate esterases was used to characterize new bacterial GEs.
2’CMA was used as a positive control in the study evaluating HSP70 inhibitors as antivirals for ZIKV infection.
Glycosyltransferase inhibitors 2FF and 2FG allow generation of antibodies with low fucose and galactose glyco-profile.
Acetylated 5-alkynylfucose (MA45977) is a potent inhibitor of IgG fucosylation
Esterification with pyroglutamic acid and loading of IDE (BI164565) into solid lipid nanoparticles enhances hydrating ability
Inhibition of O-GlcNAcases by thiamet G (MD08856) increases O-GlcNAcylation and Treg cell stability
Inhibitor of ERK 1/2, SCH 772984, was used to demonstrate involvement of the ERK pathway in neprilysin expression.
Kinetic studies on saponins from Zolfino bean reveal their ability to inhibit aldose reductase.
Human hepatocyte-like cell lines were infected with Zika virus and treated with RNA polymerase inhibitors.
Biochemical studies investigating uptake and catabolism of MurNAc and its role in cell wall metabolism
Patients with Marinesco-Sjögren-like syndrome were tested for the enzymatic activity of GBA2
Anti-angiogenic effect of sialyllactose is mediated by suppressing VEGFR-2 activation
T-synthase is a key enzyme for O-glycan synthesis and can be detected with fluorescent assay using 4MU-conjugated donor.
Finasteride and dutasteride reduced adverse effects of anti-parkinsonian therapy.
Oridonin and forskolin reduced neuroinflammation and restored behavioural deficits in Alzheimer's disease model.
An alternative route of synthesis using FAC from Carbosynth (ND08343).
Inhibiting lactate importer MCT1 reverses lactate-induced resistance in cancer cells.
Inhibitors that specifically target the polyol pathway are desirable, indicated by preferential reduction in L-idose (MI04205)
Viral envelope N-glycans interact with L-selectin on central memory T cells.
Bacterial toxin scavenging particles displaying GM1 ganglioside efficiently attenuate cholera toxin symptoms.
O-GlcNAc cycling enzymes are mutually controlled at the transcriptional level.
Lactulose (OL03995) as substrate for synthesis of HMO-mimics via the one-pot two-enzyme system
SN 38 (FE29579) and biotin in a theranostic compound detects and treats hypoxic solid tumors.
E. coli overgrowth depends on free sialidases secreted by other components of gut microbiome.
Iduronate-2-sulfatase delivery to brain corrects MPS II symptoms.
Adapter is linked to the 3' end of ssDNA via click reaction and then converted into dsDNA.
The sensitivity of avian influenza A (H5N1) viruses, of clade 2.1, to NAIs was tested.
Transport and metabolism of LacNAC, from Carbosynth, by L. casei.
Temozolomide causes defects in DNA mismatch repair mechanism.
LacNAc capping causes hyperproliferation of stem cells in crypts.
JQ1 was used to investigate the role of BET-induced transcriptional regulation by BRD2,3,4 and BRDT.
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