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Literature > Citations

Biosynth Carbosynth products are widely used by scientific community and cited in peer-reviewed, high impact journals on a daily basis. We highlight 3 top publications every month but you can find a full list of papers citing our molecules here.

2020 Citations

Protease inhibitor camostat mesylate inhibits Coronavirus entry in cells

Inhibition of a specific cellular protease by camostat mesylate results in lower SARS-CoV-2 infectivity


Detection of carbapenem-resistant bacteria with a novel chemiluminescence probe

The chemiluminescence-based enzyme substrates are promising candidates for new generation diagnostics.

2019 Citations

Scleroglucan, an alternative to xanthan gum-based food thickeners for patients with swal...

Scleroglucan is a promising agent with the potential to alleviate extensive thirst in patients with swallowing disorder.


6’-sialylgalactose inhibits angiogenesis and tumour growth

6'-sialylgalactose was efficient in inhibiting new vessel formation in tumours as well in a model of retinopathy.

Nicotinamide riboside crystals and X-ray structure revealed

This research was co-developed by prof. Spingler from the University of Zürich and scientists from Biosynth Carbosynth.


Kidney bean extract prevents and protects from metabolic syndrome markers

The effects of the bean extract were comparable to reference drugs metformin and atorvastatin.

Drug repurposing: fluoxetine has antiviral activity against Enteroviruses

(S)-fluoxetine enantiomer inhibits replication of enteroviruses by binding to the non-structural protein 2C.

The role of α-fucosidases in S. pneumoniae infection

Lewis antigens and H blood group antigens were used to characterize two bacterial α-fucosidases.


GT1b oligosaccharide for determining structure of infectious BK polyomavirus

The structure of BKV in complex with GT1b (OO16323) will aid in developing new therapies.


Antiviral compound 7-DMA reduces ZIKA reproductive potential in mice testicles

Viral polymerase inhibitor 7-deaza-2’-C-methyladenosine reduces the load of viral RNA and infectious virus in mice testicles.

Sialyllactose promotes differentiation of gut epithelium and wound healing

6’-sialyllactose and 3’-sialyllactose regulate functioning of intestinal epithelium.


Human milk oligosaccharides and rotavirus infection

Prebiotic and human milk oligosaccharides ameliorate rotavirus-induced diarrhea in animal models.

New protocol for electroporation allows protein delivery into plant cells

X-glucuronide was used for the visualisation of expression of the reporter enzyme ß-glucuronidase (GUS).

Crystal structure of a mammalian nucleotide-sugar transporter

CMP-sialic acid was used to study mechanisms of substrate selectivity of CMP-sialic acid transproter.


Protective effects of a chitohexaose analog from polymicrobial sepsis

AVR-25 binds to TLR4 and induces anti-inflammatory cytokine IL-10, reducing organ damage and mortality

Novel, direct and chemical method of quantifying 5-Azacytidines in the genome

This method will help to understand therapeutic resistance in patients treated with these compounds

Bioanalytical assay for quantifying FGFR4 inhibitor BLU 554

This novel LC-MS/MS-based method can be beneficial for future pre-clinical and clinical studies


Bacterial glucuronoyl esterases can aid degradation of lignocellulose

A range of substrates for carbohydrate esterases was used to characterize new bacterial GEs.

Antiviral reference standard for the evaluation of new antiviral therapeutics

2’CMA was used as a positive control in the study evaluating HSP70 inhibitors as antivirals for ZIKV infection.

Specific glycosyltransferase inhibitors for the control of antibody glycoforms

Glycosyltransferase inhibitors 2FF and 2FG allow generation of antibodies with low fucose and galactose glyco-profile.


Efficacy of fucose analogues and their acetylated forms on IgG glycosylation

Acetylated 5-alkynylfucose (MA45977) is a potent inhibitor of IgG fucosylation

Improving antioxidant activity and topical efficacy of idebenone

Esterification with pyroglutamic acid and loading of IDE (BI164565) into solid lipid nanoparticles enhances hydrating ability

O-GlcNAcylation maintains lineage stability of regulatory T cells.

Inhibition of O-GlcNAcases by thiamet G (MD08856) increases O-GlcNAcylation and Treg cell stability


Serotonin metabolite 5-HIAA up-regulates the expression of neprilysin

Inhibitor of ERK 1/2, SCH 772984, was used to demonstrate involvement of the ERK pathway in neprilysin expression.

Soyasaponin Bb acts as aldose reductase differential inhibitor

Kinetic studies on saponins from Zolfino bean reveal their ability to inhibit aldose reductase.

7-DMA inhibits Zika virus replication in hepatocyte-like cells of stem cell origin

Human hepatocyte-like cell lines were infected with Zika virus and treated with RNA polymerase inhibitors.

2018 Citations

Characterization of MurNAc kinase in T. forsythia

Biochemical studies investigating uptake and catabolism of MurNAc and its role in cell wall metabolism

AMP-Deoxynojirimycin for specific inhibition of GBA2 activity

Patients with Marinesco-Sjögren-like syndrome were tested for the enzymatic activity of GBA2

Role of sialylated human milk oligosaccharides in inhibiting angiogenesis

Anti-angiogenic effect of sialyllactose is mediated by suppressing VEGFR-2 activation


O-glycosylation is crucial for exocrine and endocrine pancreatic function

T-synthase is a key enzyme for O-glycan synthesis and can be detected with fluorescent assay using 4MU-conjugated donor.

5α-reductase inhibitors ameliorate L-DOPA-induced dyskinesia

Finasteride and dutasteride reduced adverse effects of anti-parkinsonian therapy.

Neuroprotective effects of natural diterpenoids in cerebral amyloidosis models

Oridonin and forskolin reduced neuroinflammation and restored behavioural deficits in Alzheimer's disease model.


Synthesis of [18F]FAC using TMSOTf-assisted system

An alternative route of synthesis using FAC from Carbosynth (ND08343).

AZD 3965 prevents resistance to MET inhibitors

Inhibiting lactate importer MCT1 reverses lactate-induced resistance in cancer cells.

L-idose as a substrate for aldose reductase to identify differential inhibitors

Inhibitors that specifically target the polyol pathway are desirable, indicated by preferential reduction in L-idose (MI04205)


L-selectin controls HIV-1 adhesion and viral release from T cells

Viral envelope N-glycans interact with L-selectin on central memory T cells.

GM1 ganglioside-coated nanoparticles for cholera toxin neutralization

Bacterial toxin scavenging particles displaying GM1 ganglioside efficiently attenuate cholera toxin symptoms.

Thiamet G for the study of O-GlcNAc homeostasis in pancreatic cancer

O-GlcNAc cycling enzymes are mutually controlled at the transcriptional level.


Chemoenzymatic synthesis of sialylated lactuloses

Lactulose (OL03995) as substrate for synthesis of HMO-mimics via the one-pot two-enzyme system

SN 38 as diagnostic fluorophore and anti-cancer drug in solid tumors

SN 38 (FE29579) and biotin in a theranostic compound detects and treats hypoxic solid tumors.


Sialic acid catabolism drives intestinal inflammation

E. coli overgrowth depends on free sialidases secreted by other components of gut microbiome.

Brain-targeted therapy corrects MPS II

Iduronate-2-sulfatase delivery to brain corrects MPS II symptoms.

Next-generation sequencing library preparation from single-stranded DNA

Adapter is linked to the 3' end of ssDNA via click reaction and then converted into dsDNA.


MUNANA for fluorescence-based enzyme inhibition assay

The sensitivity of avian influenza A (H5N1) viruses, of clade 2.1, to NAIs was tested.

LacNAc is metabolized by L. casei

Transport and metabolism of LacNAC, from Carbosynth, by L. casei.

Inactivation of DNA repair mechanism impairs tumour growth

Temozolomide causes defects in DNA mismatch repair mechanism.


LacNAc for assessing intestinal crypt function

LacNAc capping causes hyperproliferation of stem cells in crypts.

BET family inhibitor JQ1 for studying protein homeostasis

JQ1 was used to investigate the role of BET-induced transcriptional regulation by BRD2,3,4 and BRDT.

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