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BG166664

GSK 626616 - Bio-X

Potent inhibitor of dual specificity tyrosine-phosphorylation-regulated kinase 3 (DYRK3) and yanus kinase (YAK3), with IC50 values of 0.7 nM for DYRK3. Elevates hemoglobin and platelet levels in anemic mice.

Technical Data

CAS No: 1025821-33-3
Product Code: BG166664
Chemical Formula: C18H10Cl2N4OS
Molecular Weight: 401.27

References


  • Erickson-Miller CL et al (2007). GSK626616: A DYRK3 Inhibitor as a Potential New Therapy for the Treatment of Anemia. Blood 110(11): 510.
  • Wippich F et al (2013). Dual specificity kinase DYRK3 couples stress granule condensation/dissolution to mTORC1 signaling. Cell 152(4):791-805.
  • Rai AK et al (2018). Kinase-controlled phase transition of membraneless organelles in mitosis. Nature 559(7713):211-216.

Solubility

Stability

Further Information


Datasheets


GSK 626616 - Bio-X

CAS No:
1025821-33-3
Chemical Formula:
Molecular Weight:
401.27
Product Structure
References:
1. Erickson-Miller CL et al (2007). GSK626616: A DYRK3 Inhibitor as a Potential New Therapy for the Treatment of Anemia. Blood 110(11): 510.
2. Wippich F et al (2013). Dual specificity kinase DYRK3 couples stress granule condensation/dissolution to mTORC1 signaling. Cell 152(4):791-805.
3. Rai AK et al (2018). Kinase-controlled phase transition of membraneless organelles in mitosis. Nature 559(7713):211-216.

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