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BA41291
BIO-X

A 66 NEW

Specific inhibitor of the phosphoinositide 3-kinase (PI3K) alpha subunit with IC50 of 32 nM. In heart muscle it negatively regulates hypertrophic growth, causes increase in late sodium current and leads to arrhythmias. In tumours it inhibits the p110α subunit of PI3K and blocks growth factor signalling resulting in reduced tumour growth.

Technical Data

CAS No: 1166227-08-2
Synonyms: (2S)-N1-(5-(2-tert-Butylthiazol-4-yl)-4-methylthiazol-2-yl)pyrrolidine-1,2-dicarboxamide
Product Code: BA41291
MDL No: MFCD22378485
Chemical Formula: C17H23N5O2S2
Molecular Weight: 393.53

References


  • Toischer et al., 2018. Role of late sodium current as a potential arrhythmogenic mechanism in the progression of pressure-induced heart disease. J Mol Cell Cardiol. 61:111-22.
  • Jamieson et al., 2011. A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types. Biochem J. 438(Pt 1): 53–62.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

A 66 - Bio-X

CAS No:
1166227-08-2
Synonyms:
(2S)-N1-(5-(2-tert-Butylthiazol-4-yl)-4-methylthiazol-2-yl)pyrrolidine-1,2-dicarboxamide
MDL No:
MFCD22378485
Chemical Formula:
Molecular Weight:
393.53
Product Structure
References:
1. Toischer et al., 2018. Role of late sodium current as a potential arrhythmogenic mechanism in the progression of pressure-induced heart disease. J Mol Cell Cardiol. 61:111-22.
2. Jamieson et al., 2011. A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types. Biochem J. 438(Pt 1): 53–62.
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