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BW168424
BIO-X

WS 383

Potent inhibitor of the interaction between defective cullin neddylation protein DCN1 and NEDD8-conjugating enzyme UBC12 with IC50 of 11 nM. WS 383 blocks the DCN1-UBC12 interaction in a reversible manner, selectively inhibits Cul3/1 neddylation and induces accumulation of p21, p27, and NRF2 proteins.

Technical Data

CAS No: 2247543-65-1
Synonyms: 5-[[2-[[(4-Chlorophenyl)methyl]thio]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]thio]-N,N-dimethyl-H-tetrazole-1-ethanamine
Product Code: BW168424
Chemical Formula: C18H20ClN9S2
Molecular Weight: 462.00

References


  • Wang S et al (2019). Development of Highly Potent, Selective, and Cellular Active Triazolo[1,5-a]pyrimidine-Based Inhibitors Targeting the DCN1–UBC12 Protein–Protein Interaction. J Med Chem 62: 2772-2797.

Solubility

Stability

Further Information


Datasheets


CAS No:
2247543-65-1
Synonyms:
5-[[2-[[(4-Chlorophenyl)methyl]thio]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]thio]-N,N-dimethyl-H-tetrazole-1-ethanamine
Chemical Formula:
Molecular Weight:
462.00
Product Structure
References:
1. Wang S et al (2019). Development of Highly Potent, Selective, and Cellular Active Triazolo[1,5-a]pyrimidine-Based Inhibitors Targeting the DCN1–UBC12 Protein–Protein Interaction. J Med Chem 62: 2772-2797.

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