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BB168529
BIO-X

Bragsin 2 NEW

Inhibitor of BRAG2-mediated activation of Arf GTP-ase. In vitro experiments showed that Bragsin2 inhibits the Arf GTP-ase activation that is mediated by a nucleotide exchange factor BRAG2 in a membrane-dependent manner. Bragsin2 interacts with the PH domain of BRAG2 protein as well as membrane, which prevents the activation of lipidated Arf. Bragsin2 affects the trans-Golgi network and was shown to affect the tumour sphere in breast cancer cell lines.

Technical Data

CAS No: 342795-08-8
Synonyms: 6-Methoxy-5-nitro-2-(trifluoromethyl)-4H-1-benzopyran-4-one; Bragsin2
Product Code: BB168529
Chemical Formula: C11H6F3NO5
Molecular Weight: 289.16

References


  • Nawrotek A et al (2019). PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling. Nat Chem Biol 15(4): 358-366.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
342795-08-8
Synonyms:
6-Methoxy-5-nitro-2-(trifluoromethyl)-4H-1-benzopyran-4-one
Bragsin2
Chemical Formula:
Molecular Weight:
289.16
Product Structure
References:
1. Nawrotek A et al (2019). PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling. Nat Chem Biol 15(4): 358-366.
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