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BC162488
BIO-X

CHIR 99021 hydrochloride

Potent and selective inhibitor of the glycogen synthase kinase GSK-3. Promotes cell renewal in embryonic stem cells by modulating Notch, MAPK and TGF-β signalling pathways, which are involved in pluripotency. It also affects the Wnt/β-catenin pathway and alters expression of genes coding for proteins, epigenetic regulatory elements and non-coding RNAs. The combination of CHIR 99021 and basic fibroblast growth factor (bFGF) allows long-term self-renewal in adult mouse retinal progenitor cells.

Technical Data

CAS No: 1797989-42-4
Product Code: BC162488
MDL No: MFCD23704170
Chemical Formula: C22H18Cl2N8·HCl
Molecular Weight: 501.80

References


  • Wu et al (2013). CHIR99021 promotes self-renewal of mouse embryonic stem cells by modulation of protein-encoding gene and long intergenic non-coding RNA expression. Experimental Cell Research 319(17):2684-2699.
  • Jin et al (2018). The combination of bFGF and CHIR99021 maintains stable self-renewal of mouse adult retinal progenitor cells. Stem Cell Research and Therapy 9:346.

Solubility

Stability

Further Information


Datasheets


CAS No:
1797989-42-4
MDL No:
MFCD23704170
Chemical Formula:
Molecular Weight:
501.80
Product Structure
References:
1. Wu et al (2013). CHIR99021 promotes self-renewal of mouse embryonic stem cells by modulation of protein-encoding gene and long intergenic non-coding RNA expression. Experimental Cell Research 319(17):2684-2699.
2. Jin et al (2018). The combination of bFGF and CHIR99021 maintains stable self-renewal of mouse adult retinal progenitor cells. Stem Cell Research and Therapy 9:346.

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