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NC16650

CGS 21680 HCl - Bio-X NEW

Selective A2 adenosine receptor agonist. Increases cardiac output in rats with acute heart failure, mediated by reduced venous resistance and raised heart rate. Demonstrates neuroprotective properties by lowering blood cell infiltrates and neuroinflammation in ischemic cerebral tissue. 

Technical Data

CAS No: 124431-80-7
Synonyms: 2-p-(2-Carboxyethyl)phenethylamino-5′-N-ethylcarboxamidoadenosine hydrochloride; 4-[2-[[6-Amino-9-(N-ethyl-b-D-ribofuranuronamidosyl)-9H-purin-2-yl]amino]ethyl]benzenepropanoic acid hydrochloride
Product Code: NC16650
MDL No: MFCD00078573
Chemical Formula: C23H30ClN7O6
Molecular Weight: 535.98

References


  • Nekooeian AA and Tabrizchi R (1998). Effects of CGS 21680, a selective A2A adenosine receptor agonist, on cardiac output and vascular resistance in acute heart failure in the anaesthetized rat. Br J Pharmacol 123(8):1666-72.
  • Melani A et al (2014). Low doses of the selective adenosine A2A receptor agonist CGS21680 are protective in a rat model of transient cerebral ischemia. Brain Res 1551:59-72.

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Further Information


Datasheets

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CGS 21680 HCl - Bio-X

CAS No:
124431-80-7
Synonyms:
2-p-(2-Carboxyethyl)phenethylamino-5′-N-ethylcarboxamidoadenosine hydrochloride
4-[2-[[6-Amino-9-(N-ethyl-b-D-ribofuranuronamidosyl)-9H-purin-2-yl]amino]ethyl]benzenepropanoic acid hydrochloride
MDL No:
MFCD00078573
Chemical Formula:
Molecular Weight:
535.98
Product Structure
References:
1. Nekooeian AA and Tabrizchi R (1998). Effects of CGS 21680, a selective A2A adenosine receptor agonist, on cardiac output and vascular resistance in acute heart failure in the anaesthetized rat. Br J Pharmacol 123(8):1666-72.
2. Melani A et al (2014). Low doses of the selective adenosine A2A receptor agonist CGS21680 are protective in a rat model of transient cerebral ischemia. Brain Res 1551:59-72.
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