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BN167096

Nexinhib20 - Bio-X

Inhibits interaction between small GTPase Rab27a and its effector JFC1 (synaptotagmin-like protein1, Slp1). These proteins regulate neutrophil exocytosis, decrease neutrophil infiltration in liver and kidneys and reduce extracellular ROS production by NAPDH oxidase. Thus, nexinhibib20 suppresses systemic inflammation.

Technical Data

CAS No: 331949-35-0
Product Code: BN167096
Chemical Formula: C15H16N4O3
Molecular Weight: 300.31

References


  • Johnson JL et al (2016). Identification of Neutrophil Exocytosis Inhibitors (Nexinhibs), Small Molecule Inhibitors of Neutrophil Exocytosis and Inflammation: DRUGGABILITY OF THE SMALL GTPase Rab27a. J Biol Chem 291(50):25965-25982.

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Further Information


Datasheets


Nexinhib20 - Bio-X

CAS No:
331949-35-0
Chemical Formula:
Molecular Weight:
300.31
Product Structure
References:
1. Johnson JL et al (2016). Identification of Neutrophil Exocytosis Inhibitors (Nexinhibs), Small Molecule Inhibitors of Neutrophil Exocytosis and Inflammation: DRUGGABILITY OF THE SMALL GTPase Rab27a. J Biol Chem 291(50):25965-25982.

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