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BC164191

CA3 - Bio-X NEW

Inhibits YAP/Tead transcriptional activity. Has anti-tumour effects on oesophageal adenocarcinoma with therapeutic potential in combination with 5-FU. Involved in ferroptosis, mediated by iron-dependent ROS.

Technical Data

CAS No: 300802-28-2
Synonyms: 1,1'-[[9-(hydroxyimino)-9H-fluorene-2,7-diyl]bis(sulfonyl)]bis- (9CI); CIL 56
Product Code: BC164191
Chemical Formula: C23H27N3O5S2
Molecular Weight: 489.61

Literature


  • Shimada K et al (2016). Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis. Nat Chem Biol 12(7):497-503.
  • Song S et al (2018). A Novel YAP1 Inhibitor Targets CSC-Enriched Radiation-Resistant Cells and Exerts Strong Antitumor Activity in Esophageal Adenocarcinoma. Mol Cancer Ther 17(2):443-454.

Solubility

Stability

Further Information


Datasheets

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MSDS: View

CA3 - Bio-X

CAS No:
300802-28-2
Synonyms:
1,1'-[[9-(hydroxyimino)-9H-fluorene-2,7-diyl]bis(sulfonyl)]bis- (9CI)
CIL 56
Chemical Formula:
Molecular Weight:
489.61
Product Structure
References:
1. Shimada K et al (2016). Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis. Nat Chem Biol 12(7):497-503.
2. Song S et al (2018). A Novel YAP1 Inhibitor Targets CSC-Enriched Radiation-Resistant Cells and Exerts Strong Antitumor Activity in Esophageal Adenocarcinoma. Mol Cancer Ther 17(2):443-454.
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