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BL165195
BIO-X

LU 005i

Potent inhibitor of β5i subunit of immunoproteasomes (IC50 = 6.6 nM), selective over β5c subunit (IC50 = 287 nM). The β5i subunit of immunoproteasomes (iCPs) is the chymotrypsin-like active sites that have implications on anti-cancer affects. On the other hand, β5c subunits are found in constitutive proteasomes (cCPs). 

Technical Data

CAS No: 1620107-33-6
Product Code: BL165195
Chemical Formula: C31H46N4O7
Molecular Weight: 586.72

References


  • de Bruin G et al (2014). Structure-based design of β1i or β5i specific inhibitors of human immunoproteasomes. J Med Chem 57(14):6197-209.

Solubility

Stability

Further Information


Datasheets


LU 005i - Bio-X

CAS No:
1620107-33-6
Chemical Formula:
Molecular Weight:
586.72
Product Structure
References:
1. de Bruin G et al (2014). Structure-based design of β1i or β5i specific inhibitors of human immunoproteasomes. J Med Chem 57(14):6197-209.

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