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BW166844
BIO-X

WM 8014 NEW

Selective and potent inhibitor of lysine acetyltransferases KAT6A and KAT6B with IC50 values of 8 nM and 28 nM, respectively. The compound is a reversible competitor of acetyl coenzyme A domain of KAT6A/B enzymes. It inhibits MYST-catalysed histone acetylation and potentiates senescence in vitro and in zebrafish model of hepatocellular carcinoma. The compound opened the door to a new class of cancer therapeutics that could potentially direct the cancer cells in senescence or permanent dormancy.

Technical Data

CAS No: 2055397-18-5
Synonyms: MOZ-IN-3
Product Code: BW166844
MDL No: MFCD31630714
Chemical Formula: C20H17FN2O3S
Molecular Weight: 384.43

References


  • Baell et al (2018). Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth. Nature 560:253–257.
  • Huang (2018). New KAT6 inhibitors induce senescence and arrest cancer growth. Synthetic and Systems Biotechnology 3(4):244-245.
  • Leaver et al (2019) Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A. J. Med. Chem. 62, 7146

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
2055397-18-5
Synonyms:
MOZ-IN-3
MDL No:
MFCD31630714
Chemical Formula:
Molecular Weight:
384.43
Product Structure
References:
1. Baell et al (2018). Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth. Nature 560:253–257.
2. Huang (2018). New KAT6 inhibitors induce senescence and arrest cancer growth. Synthetic and Systems Biotechnology 3(4):244-245.
3. Leaver et al (2019) Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A. J. Med. Chem. 62, 7146
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