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BG163813
BIO-X

GSK 583 NEW

A potent and selective inhibitor of cell death-inducing kinase RIP2 (IC50 = 5 nM). Reduces release of pro-inflammatory cytokines. Inhibits production of TNF-α and IL-6 in intestinal explants from patients with Crohn's disease and ulcerative colitis.

Technical Data

CAS No: 1346547-00-9
Synonyms: 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine
Product Code: BG163813
Chemical Formula: C20H19FN4O2S
Molecular Weight: 398.46

Literature

References
  • Wang H et al (2017). Rip2 Is Required for Nod2-Mediated Lysozyme Sorting in Paneth Cells. J Immunol 198(9):3729-3736.

Solubility

Stability

Datasheets

Specification: View
MSDS: View

GSK 583 - Bio-X

CAS No:
1346547-00-9
Synonyms:
6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine
Chemical Formula:
Molecular Weight:
398.46
Product Structure
References:
1. Wang H et al (2017). Rip2 Is Required for Nod2-Mediated Lysozyme Sorting in Paneth Cells. J Immunol 198(9):3729-3736.
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