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BW164081

WNK463 monohydrate - Bio-X NEW

A pan-WNK kinase inhibitor, acting on WNK1, WNK2, WNK3, and WNK4 kinases. Affects blood pressure, heart rate, body fluid and electrolyte homeostasis in rodent models of hypertension.

Technical Data

CAS No: 2012607-27-9
Synonyms: N-(1,1-Dimethylethyl)-1-[1-[5-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]-2-pyridinyl]-4-piperidinyl]-1H-imidazole-5-carboxamide
Product Code: BW164081
Chemical Formula: C21H24F3N7O2·H2O
Molecular Weight: 481.47

References


  • Yamada K et al (2016). Small-molecule WNK inhibition regulates cardiovascular and renal function. Nat Chem Biol 12(11):896-898.
  • Zhang J et al (2016). Leveraging unique structural characteristics of WNK kinases to achieve therapeutic inhibition. Sci Signal 9(450):e3.

Solubility

Stability

Further Information


Datasheets

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MSDS: View

WNK463 monohydrate - Bio-X

CAS No:
2012607-27-9
Synonyms:
N-(1,1-Dimethylethyl)-1-[1-[5-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]-2-pyridinyl]-4-piperidinyl]-1H-imidazole-5-carboxamide
Chemical Formula:
Molecular Weight:
481.47
Product Structure
References:
1. Yamada K et al (2016). Small-molecule WNK inhibition regulates cardiovascular and renal function. Nat Chem Biol 12(11):896-898.
2. Zhang J et al (2016). Leveraging unique structural characteristics of WNK kinases to achieve therapeutic inhibition. Sci Signal 9(450):e3.
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