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BB167807
BIO-X

BMS 823778 hydrochloride

Selective, potent, competitive and reversible inhibitor of human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) with IC50 of 2.3 nM and more than 10000-fold selectivity over the related 11β-HSD-2 isoform. BMS 823778 inhibits conversion of cortisone in cortisol and has applications in the treatment of diabetes type 2 since it can influence the occurrence of insulin resistance.

Technical Data

CAS No: 1140898-87-8
Product Code: BB167807
MDL No: MFCD30718574
Chemical Formula: C18H18ClN3O·HCl
Molecular Weight: 364.27

References


  • Li et al (2018). Discovery of Clinical Candidate BMS-823778 as an Inhibitor of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1). ACS Medicinal Chemistry Letters 9(12):1170-1174.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
1140898-87-8
MDL No:
MFCD30718574
Chemical Formula:
Molecular Weight:
364.27
Product Structure
References:
1. Li et al (2018). Discovery of Clinical Candidate BMS-823778 as an Inhibitor of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1). ACS Medicinal Chemistry Letters 9(12):1170-1174.
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