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NM07918

2'-C-Methylcytidine

Broad-spectrum anti-viral; inhibitor of HCV NS5B RNA polymerase

Technical Data

CAS No: 20724-73-6
Synonyms: 2'-C-Methyl-D-cytidine
Product Code: NM07918
MDL No: MFCD02682947
Chemical Formula: C10H15N3O5
Molecular Weight: 257.25

References


  • Migliaccio G et al (2003). Characterization of Resistance to Non-obligate Chain-terminating Ribonucleoside Analogs That Inhibit Hepatitis C Virus Replication in Vitro. J Bio Chem 278:49164–49170.
  • Pierra C et al (2006). Synthesis and Pharmacokinetics of Valopicitabine (NM283), an Efficient Prodrug of the Potent Anti-HCV Agent 2‘-C-Methylcytidine. J Med Chem 49(22): 6614–6620.
  • De Clercq E (2007). The design of drugs for HIV and HCV. Nat Rev Drug Discov 6(12):1001-1018.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View
Technical Bulletin: View

2'-C-Methylcytidine

CAS No:
20724-73-6
Synonyms:
2'-C-Methyl-D-cytidine
MDL No:
MFCD02682947
Chemical Formula:
Molecular Weight:
257.25
Product Structure
References:
1. Migliaccio G et al (2003). Characterization of Resistance to Non-obligate Chain-terminating Ribonucleoside Analogs That Inhibit Hepatitis C Virus Replication in Vitro. J Bio Chem 278:49164–49170.
2. Pierra C et al (2006). Synthesis and Pharmacokinetics of Valopicitabine (NM283), an Efficient Prodrug of the Potent Anti-HCV Agent 2‘-C-Methylcytidine. J Med Chem 49(22): 6614–6620.
3. De Clercq E (2007). The design of drugs for HIV and HCV. Nat Rev Drug Discov 6(12):1001-1018.
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