Availability
0
Your Basket is Empty
BD164356

Daunorubicin HCl - Bio-X

Anthracycline antibiotic with potent anti-tumoral activity. The compound interferes with DNA replication and RNA transcription since it intercalates between the base pairs of nucleic acids. It also inhibits the topoisomerase II, proteasome and generates free radicals, which leads to cell death of treated cells. Moreover, daunorubicin triggers apoptosis trough the stimulation of ceramide synthesis. It has been used as chemotherapy agent for the treatment of myeloid leukaemia (AML) and acute lymphocytic leukaemia (ALL).

Technical Data

CAS No: 23541-50-6
Synonyms: Daunomycin, HCl
Product Code: BD164356
MDL No: MFCD08063720
Chemical Formula: C27H29NO10·HCl
Molecular Weight: 563.98

Literature


  • Belloc et al., 1992. Intercalation of Anthracyclines into Living Cell DNA Analyzed by Flow Cytometry. Cytometry 13(8):880-885.
  • Bose et al., 1995. Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals. Cell 82(3):405-14.
  • Laurent and Jaffrézou, 2001. Signaling pathways activated by daunorubicin. Blood 98(4):913-24.

Solubility

Stability

Further Information


Datasheets


Daunorubicin HCl - Bio-X

CAS No:
23541-50-6
Synonyms:
Daunomycin, HCl
MDL No:
MFCD08063720
Chemical Formula:
Molecular Weight:
563.98
Product Structure
References:
1. Belloc et al., 1992. Intercalation of Anthracyclines into Living Cell DNA Analyzed by Flow Cytometry.
Cytometry 13(8):880-885.

2. Bose et al., 1995. Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals. Cell 82(3):405-14.
3. Laurent and Jaffrézou, 2001. Signaling pathways activated by daunorubicin. Blood 98(4):913-24.

For requirements greater than the catalogue prepacks email: enquiries@carbosynth.com

Custom Synthesis

For custom synthesis or special requests email: enquiries@carbosynth.com, call +44 (0)1635 578444 or fill out our contact form

Please Wait...