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BB168411
BIO-X

BRD 3308

Inhibitor of histone deacetylase 3 (HDAC3) with IC50 in nanomolar range. BRD 9908 was shown to preserve the insulin-secreting pancreatic cells in nonobese diabetic mice. BRD 3308 supressed infiltration of mononuclear cells and prevented β-cell death in vivo as well as increased basal insulin secretion in vitro. Studies on HIV infection models showed that HDAC3 inhibition by BRD 3308 disrupts the HIV latency by increasing the gene expression from HIV promoter.

Technical Data

CAS No: 1550053-02-5
Synonyms: 4-4-Acetamido-N-(2-amino-4-fluorophenyl)benzamide; BRD3308
Product Code: BB168411
Chemical Formula: C15H14FN3O2
Molecular Weight: 287.29

References


  • Dirice et al (2017). Isoform-selective inhibitor of histone deacetylase 3 (HDAC3) limits pancreatic islet infiltration and protects female nonobese diabetic mice from diabetes. Journal of Biological Chemistry 292(43):17598-17608.
  • Barton et al (2014). Selective HDAC Inhibition for the Disruption of Latent HIV-1 Infection. PLoS ONE 9(8):e102684.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
1550053-02-5
Synonyms:
4-4-Acetamido-N-(2-amino-4-fluorophenyl)benzamide
BRD3308
Chemical Formula:
Molecular Weight:
287.29
Product Structure
References:
1. Dirice et al (2017). Isoform-selective inhibitor of histone deacetylase 3 (HDAC3) limits pancreatic islet infiltration and protects female nonobese diabetic mice from diabetes. Journal of Biological Chemistry 292(43):17598-17608.
2. Barton et al (2014). Selective HDAC Inhibition for the Disruption of Latent HIV-1 Infection. PLoS ONE 9(8):e102684.
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