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BO167098
BIO-X

O8 OGG1 Inhibitor

Specific inhibitor of 8-oxoguanine DNA glycosylase OGG1 with IC50 of 0.22 μM. OGG1 is a key enzyme in DNA repair mechanism called base excision repair (BER). The compound inhibits the hydrolysis of glycosidic bond required for the excision of 8-oxoguanine from double stranded DNA, which leads to accumulation of mutations. It has been proposed as monotherapy for certain types of cancers. It may also be used as adjuvant for cancer therapy as it was seen to sensitize tumors for chemotherapy.

Technical Data

CAS No: 350997-39-6
Product Code: BO167098
Chemical Formula: C9H6Cl2N2OS
Molecular Weight: 261.13

References


  • Donley N et al (2015). Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1). ACS Chem Biol 10(10):2334-43.

Solubility

Stability

Further Information


Datasheets


O8 OGG1 Inhibitor - Bio-X

CAS No:
350997-39-6
Chemical Formula:
Molecular Weight:
261.13
Product Structure
References:
1. Donley N et al (2015). Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1). ACS Chem Biol 10(10):2334-43.

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