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BG166670

GSK 1278863 - Bio-X

Inhibitor of HIF-prolyl hydroxylase isozymes PHD1, PHD2 and PHD3 with Ki in nanomolar range. The compound mimics the binding of N-oxalylglycine, chelates catalytic iron and prevents substrate entry into catalytic site. Inhibition of PHD enzymes leads to stabilization of hypoxia-induced factors HIF1α and HIF2α, followed by the production of erythropoietin (EPO).

Technical Data

CAS No: 960539-70-2
Synonyms: Daprodustat
Product Code: BG166670
Chemical Formula: C19H27N3O6
Molecular Weight: 393.43

Literature


  • Ariazi JL et al. (2017). Discovery and Preclinical Characterization of GSK1278863 (Daprodustat), a Small Molecule Hypoxia Inducible Factor-Prolyl Hydroxylase Inhibitor for Anemia. J Pharmacol Exp Ther 363(3):336-347.

Solubility

Stability

Further Information


Datasheets


GSK 1278863 - Bio-X

CAS No:
960539-70-2
Synonyms:
Daprodustat
Chemical Formula:
Molecular Weight:
393.43
Product Structure
References:
1. Ariazi JL et al. (2017). Discovery and Preclinical Characterization of GSK1278863 (Daprodustat), a Small Molecule Hypoxia Inducible Factor-Prolyl Hydroxylase Inhibitor for Anemia. J Pharmacol Exp Ther 363(3):336-347.

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