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FB18839
BIO-X

(S)-(-)-Blebbistatin

Inhibitor of myosin‐II‐specific ATPase which blocks the myosin heads in an actin-detached state, disrupts contractility of myosin-actin filaments and stabilizes super-relaxed state of muscle fibres. It inhibits skeletal muscle myosin, non-muscle myosin II and heart muscle myosin.

Technical Data

CAS No: 856925-71-8
Synonyms: (3aS)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one; (-)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one; (-)-Blebbistatin
Product Code: FB18839
MDL No: MFCD08460907
Chemical Formula: C18H16N2O2
Molecular Weight: 292.33

References


  • Straight et al (2003). Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor. Science 299(5613):1743-1747l
  • Duxbury et al (2004). Inhibition of pancreatic adenocarcinoma cellular invasiveness by blebbistatin: a novel myosin II inhibitor. Biochemical and Biophysical Research Communications 313(4):992-997.
  • Wilson et al (2014). The myosin inhibitor blebbistatin stabilizes the super-relaxed state in skeletal muscle. Biophysical Journal 107(7):1637-46.
  • Liu et al (2010). Blebbistatin inhibits contraction and accelerates migration in mouse hepatic stellate cells. British Journal of Pharmacology 159(2):304-315.
  • Kovacs et al (2004). Mechanism of Blebbistatin Inhibition of Myosin II. The Journal of Biological Chemistry 279:35557-35563.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

(S)-(-)-Blebbistatin - Bio-X

CAS No:
856925-71-8
Synonyms:
(3aS)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one
(-)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one
(-)-Blebbistatin
MDL No:
MFCD08460907
Chemical Formula:
Molecular Weight:
292.33
Product Structure
References:
1. Straight et al (2003). Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor. Science 299(5613):1743-1747l
2. Duxbury et al (2004). Inhibition of pancreatic adenocarcinoma cellular invasiveness by blebbistatin: a novel myosin II inhibitor. Biochemical and Biophysical Research Communications 313(4):992-997.
3. Wilson et al (2014). The myosin inhibitor blebbistatin stabilizes the super-relaxed state in skeletal muscle. Biophysical Journal 107(7):1637-46.
4. Liu et al (2010). Blebbistatin inhibits contraction and accelerates migration in mouse hepatic stellate cells. British Journal of Pharmacology 159(2):304-315.
5. Kovacs et al (2004). Mechanism of Blebbistatin Inhibition of Myosin II. The Journal of Biological Chemistry 279:35557-35563.
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