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BE166437
BIO-X

eCF506 NEW

Selective inhibitor of the Src kinase family with subnanomolar IC50 values and good selectivity over c-Abl, PDGFRα and c-Kit kinases. The compound is effective in inhibiting growth in drug resistant cancer cell lines. In a recent study, it inhibited the growth of HER2-positive breast cancer cell lines which were resistant to pan-HER family kinase inhibitors such as lapatinib.

Technical Data

CAS No: 1914078-41-3
Product Code: BE166437
MDL No: MFCD31657410
Chemical Formula: C26H38N8O3
Molecular Weight: 510.63

References


  • Creedon et al (2016). Identification of novel pathways linking epithelial-to-mesenchymal transition with resistance to HER2-targeted therapy. Oncotarget 7(10): 11539–11552.
  • Fraser et al (2016). Rapid Discovery and Structure–Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase. Journal of Medicinal Chemistry 59(10):4697–4710.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
1914078-41-3
MDL No:
MFCD31657410
Chemical Formula:
Molecular Weight:
510.63
Product Structure
References:
1. Creedon et al (2016). Identification of novel pathways linking epithelial-to-mesenchymal transition with resistance to HER2-targeted therapy. Oncotarget 7(10): 11539–11552.
2. Fraser et al (2016). Rapid Discovery and Structure–Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase. Journal of Medicinal Chemistry 59(10):4697–4710.
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