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BT168024
BIO-X

TH 5487 NEW

Specific inhibitor of 8-oxoguanine glycosylase OGG1 with IC50 in submicromolar range. The compound inhibits binding of OGG1 to its substrate 8-oxoguanine, a guanine analog generated in the presence of reactive oxygen species (ROS). It was shown that TH5487 decreases inflammation level by inhibiting the base excision DNA repair in mice and altering the OGG1 chromatin dynamics. The compound also has implications in cancer biology since OGG1 inhibitors sensitise tumours to chemotherapy.

Technical Data

CAS No: 2304947-71-3
Synonyms: 4-​(4-​Bromo-​2,​3-​dihydro-​2-​oxo-​1H-​benzimidazol-​1-​yl)​-​N-​(4-​iodophenyl)​-1-​piperidinecarboxamid​e; TH5487
Product Code: BT168024
Chemical Formula: C19BrH18IN4O2
Molecular Weight: 541.18

References


  • Visnes et al (2018). Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation. Science 362(6416):834-839.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
2304947-71-3
Synonyms:
4-​(4-​Bromo-​2,​3-​dihydro-​2-​oxo-​1H-​benzimidazol-​1-​yl)​-​N-​(4-​iodophenyl)​-1-​piperidinecarboxamid​e
TH5487
Chemical Formula:
Molecular Weight:
541.18
Product Structure
References:
1. Visnes et al (2018). Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation. Science 362(6416):834-839.
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