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BG167527
BIO-X

GNE 371

A chemical probe for the dual bromodomains of human transcription-initiation-factor TFIID subunit 1 (TAF1). GNE 371 binds TAF1 with an IC50 of 10 nM and is selective over other bromodomain family members. Exerts anti-proliferative effects in synergy with BET inhibitor JQ1.

Technical Data

CAS No: 1926986-36-8
Product Code: BG167527
MDL No: MFCD31735116
Chemical Formula: C24H25N5O3
Molecular Weight: 431.49

References


  • Wang S et al (2018). GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subunit 1-like. J Med Chem 61(20):9301-9315.

Solubility

Stability

Further Information


Datasheets


CAS No:
1926986-36-8
MDL No:
MFCD31735116
Chemical Formula:
Molecular Weight:
431.49
Product Structure
References:
1. Wang S et al (2018). GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subunit 1-like. J Med Chem 61(20):9301-9315.

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