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BE164406
BIO-X

Eltrombopag

Agonist of thrombopoietin receptor TpoR, which triggers activation of the JAK2/STAT5 signalling pathway. Eltrombopag is indicated in individuals with thrombocytopenia since it leads to increased proliferation of megakaryocyte progenitor cells and increased production of platelets. Eltrombopag also enhances expansion of human umbilical cord blood hematopoietic stem/primitive progenitor cells and promotes hematopoiesis.

Technical Data

CAS No: 496775-61-2
Synonyms: 3'-[2-[(2Z)-1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid; SB 497115
Product Code: BE164406
MDL No: MFCD20926253
Chemical Formula: C25H22N4O4
Molecular Weight: 442.47

References


  • Sun et al (2012). Eltrombopag, a thrombopoietin receptor agonist, enhances human umbilical cord blood hematopoietic stem/primitive progenitor cell expansion and promotes multi-lineage hematopoiesis. Stem Cell Research 9(2):77–86.
  • Erickson-Miller et al (2009). Preclinical Activity of Eltrombopag (SB-497115), an Oral, Nonpeptide Thrombopoietin Receptor Agonist. Stem Cells 27(2):424–430.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
496775-61-2
Synonyms:
3'-[2-[(2Z)-1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid
SB 497115
MDL No:
MFCD20926253
Chemical Formula:
Molecular Weight:
442.47
Product Structure
References:
1. Sun et al (2012). Eltrombopag, a thrombopoietin receptor agonist, enhances human umbilical cord blood hematopoietic stem/primitive progenitor cell expansion and promotes multi-lineage hematopoiesis. Stem Cell Research 9(2):77–86.
2. Erickson-Miller et al (2009). Preclinical Activity of Eltrombopag (SB-497115), an Oral, Nonpeptide Thrombopoietin Receptor Agonist. Stem Cells 27(2):424–430.
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