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BK164600
BIO-X

Kifunensine

Potent and specific inhibitor of plant and animal α-mannosidase I with IC50 in nanomolar range. It inhibits the enzyme isoforms in Golgi apparatus (GMI) and endoplasmatic reticulum (ERMI). The compound prevents mannose trimming on glycoproteins and shifts the glycoform content from complex to oligomannose type. Used for the production of recombinant therapeutic glycoproteins with mannose rich N-linked glycans.

Technical Data

CAS No: 109944-15-2
Synonyms: (5R,6R,7S,8R,8aS)-Hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione
Product Code: BK164600
MDL No: MFCD28988824
Chemical Formula: C8H12N2O6
Molecular Weight: 232.19

References


  • Elbein et el., 1990. Kifunensine, a Potent Inhibitor of the Glycoprotein Processing Mannosidase I. J Biol Chem 265(26):15599-605.
  • Krahn et al., 2017. Inhibition of glycosylation on a camelid antibody uniquely affects its FcγRI binding activity. Eur J Pharm Sci 96:428–439.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

Kifunensine - Bio-X

CAS No:
109944-15-2
Synonyms:
(5R,6R,7S,8R,8aS)-Hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione
MDL No:
MFCD28988824
Chemical Formula:
Molecular Weight:
232.19
Product Structure
References:
1. Elbein et el., 1990. Kifunensine, a Potent Inhibitor of the Glycoprotein Processing Mannosidase I. J Biol Chem 265(26):15599-605.
2. Krahn et al., 2017. Inhibition of glycosylation on a camelid antibody uniquely affects its FcγRI binding activity. Eur J Pharm Sci 96:428–439.
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