Availability
0
Your Basket is Empty
BB167286
BIO-X

BOS 172722

Potent inhibitor of mitotic spindle 1 (MSP1) kinase. MPS1 is a component of the spindle assembly checkpoint and is therefore involved in mitosis. Targeting MSP1 kinases has therapeutic applications in cancer and data suggests good efficacy in vivo when combining BOS 172722 with paclitaxel.

Technical Data

CAS No: 1578245-44-9
Product Code: BB167286
MDL No: MFCD31692374
Chemical Formula: C24H30N8O
Molecular Weight: 446.55

References


  • Woodward HL et al (2018). Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4- d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N2-(2-Ethoxy-4-(4-methyl-4 H-1,2,4-triazol-3-yl)phenyl)-6-methyl- N8-neopentylpyrido[3,4- d]pyrimidine-2,8-diamine (BOS172722). J Med Chem 61(18):8226-8240.

Solubility

Stability

Further Information


Datasheets


CAS No:
1578245-44-9
MDL No:
MFCD31692374
Chemical Formula:
Molecular Weight:
446.55
Product Structure
References:
1. Woodward HL et al (2018). Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4- d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N2-(2-Ethoxy-4-(4-methyl-4 H-1,2,4-triazol-3-yl)phenyl)-6-methyl- N8-neopentylpyrido[3,4- d]pyrimidine-2,8-diamine (BOS172722). J Med Chem 61(18):8226-8240.

For requirements greater than the catalogue prepacks email: enquiries@carbosynth.com

Custom Synthesis

For custom synthesis or special requests email: enquiries@carbosynth.com, call +44 (0)1635 578444 or fill out our contact form

Please Wait...