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BP166224

Palbociclib - Bio-X

Selective and potent inhibitor of cyclin-dependent kinases CDK4 and CDK6. It blocks cell cycle progression from phase G1 into S by inhibiting CDK4/6-dependent retinoblastoma (RB) phosphorylation. It has been used for the treatment of HER2 negative, estrogen receptor (ER) positive metastatic breast cancer.

Technical Data

CAS No: 571190-30-2
Product Code: BP166224
Chemical Formula: C24H29N7O2
Molecular Weight: 447.53

References


  • Finn et al., 2009. PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro. Breast Cancer Res 11(5): R77.

Solubility

Stability

Further Information


Datasheets


Palbociclib - Bio-X

CAS No:
571190-30-2
Chemical Formula:
Molecular Weight:
447.53
Product Structure
References:
1. Finn et al., 2009. PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro. Breast Cancer Res 11(5): R77.

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