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BG166815

GNE 781 - Bio-X

A selective inhibitor of the bromodomain of Cyclic adenosine monophosphate Response Element Binding protein Binding Protein (CREBBP or CBP) with anti-tumoral activity. The CBP inhibition regulates oncogene MYC and impairs differentiation of regulatory T cells.

Technical Data

CAS No: 1936422-33-1
Synonyms: 3-​[7-​(difluoromethyl)​-​3,​4-​dihydro-​6-​(1-​methyl-​1H-​pyrazol-​4-​yl)​-​1(2H)​-​quinolinyl]​-​1,​4,​6,​7-​tetrahydro-​N-​methyl-​1-​(tetrahydro-​2H-​pyran-​4-​yl)​-5H-​Pyrazolo[4,​3-​c]​pyridine-​5-​carboxamide
Product Code: BG166815
Chemical Formula: C27H33F2N7O2
Molecular Weight: 525.59

References


  • Romero AF et al (2017). GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP). J. Med. Chem 60(22):9162–9183.

Solubility

Stability

Further Information


Datasheets


GNE 781 - Bio-X

CAS No:
1936422-33-1
Synonyms:
3-​[7-​(difluoromethyl)​-​3,​4-​dihydro-​6-​(1-​methyl-​1H-​pyrazol-​4-​yl)​-​1(2H)​-​quinolinyl]​-​1,​4,​6,​7-​tetrahydro-​N-​methyl-​1-​(tetrahydro-​2H-​pyran-​4-​yl)​-5H-​Pyrazolo[4,​3-​c]​pyridine-​5-​carboxamide
Chemical Formula:
Molecular Weight:
525.59
Product Structure
References:
1. Romero AF et al (2017). GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP). J. Med. Chem 60(22):9162–9183.

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