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Research & Development
FB18939
BIO-X

Boceprevir

Inhibits HCV NS3 serine proteases in cells and HCV replicon system in vivo. Has therapeutic potential in combination with IFN therapy. Investigated in clinical studies, in combination with current standard of care treatments for HCV.

Technical Data

CAS No: 394730-60-0
Synonyms: (1R,2S,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide; EBP 520; Sch 503034
Product Code: FB18939
Chemical Formula: C27H45N5O5
Molecular Weight: 519.68

References


  • Malcolm BA et al (2006). SCH 503034, a mechanism-based inhibitor of hepatitis C virus NS3 protease, suppresses polyprotein maturation and enhances the antiviral activity of alpha interferon in replicon cells. Antimicrob Agents Chemother 50(3):1013-20.
  • Trembling PM et al (2012). Boceprevir: an oral protease inhibitor for the treatment of chronic HCV infection. Expert Rev Anti Infect Ther 10(3):269-79.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
394730-60-0
Synonyms:
(1R,2S,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
EBP 520
Sch 503034
Chemical Formula:
Molecular Weight:
519.68
Product Structure
References:
1. Malcolm BA et al (2006). SCH 503034, a mechanism-based inhibitor of hepatitis C virus NS3 protease, suppresses polyprotein maturation and enhances the antiviral activity of alpha interferon in replicon cells. Antimicrob Agents Chemother 50(3):1013-20.
2. Trembling PM et al (2012). Boceprevir: an oral protease inhibitor for the treatment of chronic HCV infection. Expert Rev Anti Infect Ther 10(3):269-79.
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