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BD164895

3-Deazaneplanocin HCl - Bio-X

Inhibitor of S-adenosylhomocysteine hydrolase that disrupts histone methylation by EZH2. Anti-proliferative in some breast cancer and invasive prostate cancer cell lines. One of four key molecules required for inducing chemical reprogramming of somatic cells into induced pluripotent stem cells (iPSC).

Technical Data

CAS No: 120964-45-6
Product Code: BD164895
Chemical Formula: C12H14N4O3·ClH
Molecular Weight: 298.73

Literature


  • Tseng CK et al (1989). Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine hydrolase with potent and selective in vitro and in vivo antiviral activities. J Med Chem 32(7):1442-6.
  • Chase A and Cross NC et al (2011). Aberrations of EZH2 in cancer. Clin Cancer Res 17(9):2613-8.
  • Hou P et al (2013). Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science 341(6146):651-4.

Solubility

Stability

Further Information


Datasheets


3-Deazaneplanocin HCl - Bio-X

CAS No:
120964-45-6
Chemical Formula:
Molecular Weight:
298.73
Product Structure
References:
1. Tseng CK et al (1989). Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine hydrolase with potent and selective in vitro and in vivo antiviral activities. J Med Chem 32(7):1442-6.
2. Chase A and Cross NC et al (2011). Aberrations of EZH2 in cancer. Clin Cancer Res 17(9):2613-8.
3. Hou P et al (2013). Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science 341(6146):651-4.

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