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BO163662

OICR 9429 - Bio-X

A highly selective WD repeat-containing protein 5 (Wdr5) antagonist and modulator of histone lysine methylation. The compound competitively disrupts the interaction between the Wdr5 and Wdr5-INteracting region (WIN) of methyltransferases. It inhibits the cell proliferation and restores differentiation in p30-dependent acute myeloid leukemia models.

Technical Data

CAS No: 1801787-56-3
Synonyms: N-[2-(4-Methylpiperazin-1-yl)-5-[3-(morpholin-4-ylmethyl)phenyl]phenyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide
Product Code: BO163662
Chemical Formula:

Literature


  • Grebien F et al. (2015). Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Nat Chem Biol 11(8):571-578.

Solubility

Stability

Further Information


Datasheets


OICR 9429 - Bio-X

CAS No:
1801787-56-3
Synonyms:
N-[2-(4-Methylpiperazin-1-yl)-5-[3-(morpholin-4-ylmethyl)phenyl]phenyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide
Chemical Formula:
Molecular Weight:
Product Structure
References:
1. Grebien F et al. (2015). Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Nat Chem Biol 11(8):571-578.

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