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BS168103
BIO-X

SGC AAK1 1

Dual inhibitor of the adaptor protein 2-associated kinase 1 (AAK1) and BMP2-inducible kinase (BMP2K) with IC50 values of 270 nM and 1 μM, respectively. In a recent study, SGC AAK1 1 stabilised β-catenin, inhibited phosphorylation of the AP2 complex subunit mu protein (AP2M1) and activated Wnt signalling in in vitro experiments.

 

Technical Data

CAS No: 2247894-32-0
Synonyms: SGC-AAK1-1; N-(6-(3-((N,N-Diethylsulfamoyl)amino)phenyl)-1H-indazol-3-yl)cyclopropanecarboxamide
Product Code: BS168103
Chemical Formula: C21H25N5O3S
Molecular Weight: 427.52

References


  • Agajanian et al (2019). WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop. Cell Reports 26:79–93.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
2247894-32-0
Synonyms:
SGC-AAK1-1
N-(6-(3-((N,N-Diethylsulfamoyl)amino)phenyl)-1H-indazol-3-yl)cyclopropanecarboxamide
Chemical Formula:
Molecular Weight:
427.52
Product Structure
References:
1. Agajanian et al (2019). WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop. Cell Reports 26:79–93.
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