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BW166843
BIO-X

WM 1119 NEW

Selective and potent inhibitor of lysine acetyltransferases KAT6A and KAT6B with IC50 values in low nanomolar range. The compound is a reversible competitor of acetyl coenzyme A domain of KAT6A/B enzymes. It inhibits MYST-catalysed histone acetylation and was shown to arrest lymphoma progression in mice models. The compound opened the door to a new class of cancer therapeutics that could potentially direct the cancer cells in senescence or permanent dormancy.

Technical Data

CAS No: 2055397-28-7
Product Code: BW166843
MDL No: MFCD31690337
Chemical Formula: C18H13F2N3O3S
Molecular Weight: 389.38

References


  • Baell et al (2018). Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth. Nature 560:253–257.
  • Huang (2018). New KAT6 inhibitors induce senescence and arrest cancer growth. Synthetic and Systems Biotechnology 3(4):244-245.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
2055397-28-7
MDL No:
MFCD31690337
Chemical Formula:
Molecular Weight:
389.38
Product Structure
References:
1. Baell et al (2018). Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth. Nature 560:253–257.
2. Huang (2018). New KAT6 inhibitors induce senescence and arrest cancer growth. Synthetic and Systems Biotechnology 3(4):244-245.
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