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BP164263
BIO-X

Paroxetine hydrochloride hemihydrate

A serotonin reuptake inhibitor with anticholinergic activity and mild inhibitory activity on noradrenaline reuptake. Paroxetine has been used for the treatment of depression, anxiety disorders, post-traumatic stress disorder, premenstrual dysphoric disorder and obsessive-compulsive disorder.  Also inhibits nitric oxide synthase and cytochrome isoenzyme P450 2D6.

Technical Data

CAS No: 110429-35-1,110429-35-1
Synonyms: (3S,4R)-(-)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine Hydrochloride Hemihydrate
Product Code: BP164263
MDL No: MFCD23843784
Chemical Formula: C19H20FNO3·HCl·1/2H2O
Molecular Weight: 374.83

References


  • Bourin M et al (2001). Paroxetine: a review. CNS Drug Rev 7(1):25-47.
  • Fujishiro J et al (2002). Comparison of the anticholinergic effects of the serotonergic antidepressants, paroxetine, fluvoxamine and clomipramine. Eur J Pharmacol 454(2-3):183-8.
  • Nevels RM et al (2016). Paroxetine—The Antidepressant from Hell? Probably Not, But Caution Required. Psychopharmacol Bull 46(1): 77–104.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
110429-35-1,110429-35-1
Synonyms:
(3S,4R)-(-)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine Hydrochloride Hemihydrate
MDL No:
MFCD23843784
Chemical Formula:
Molecular Weight:
374.83
Product Structure
References:
1. Bourin M et al (2001). Paroxetine: a review. CNS Drug Rev 7(1):25-47.
2. Fujishiro J et al (2002). Comparison of the anticholinergic effects of the serotonergic antidepressants, paroxetine, fluvoxamine and clomipramine. Eur J Pharmacol 454(2-3):183-8.
3. Nevels RM et al (2016). Paroxetine—The Antidepressant from Hell? Probably Not, But Caution Required. Psychopharmacol Bull 46(1): 77–104.
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