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BV165163
BIO-X

VU 6010608 NEW

This compound is a novel glutamate metabotropic receptor mGlu7 negative allosteric modulator. It is highly selective for mGlu7 over other receptors of mGlu class with IC50 = 795 nM. Although VU 6010608 showed favourable brain penetration in rats, it has been proposed as an in vitro tool for electrophysiology studies. The mGlu7 is broadly distributed within the mammalian central nervous system and it plays a key role in neuronal function and synaptic plasticity.

Technical Data

CAS No: 2165325-42-6
Synonyms: 3,​4-​Dimethoxy-​N-​[2-​(1H-​1,​2,​4-​triazol-​1-​yl)​-​5-​(trifluoromethoxy)​phenyl]​-benzamide
Product Code: BV165163
Chemical Formula: C18H15F3N4O4
Molecular Weight: 408.33

Literature

References
  • Reed et al., 2017. VU6010608, a Novel mGlu7 NAM from a Series of N-(2-(1H-1,2,4-Triazol-1-yl)-5-(trifluoromethoxy)phenyl)benzamides. ACS Med Chem Lett. 8(12):1326-1330.

Solubility

Stability

Datasheets

Specification: View
MSDS: View

VU 6010608 - Bio-X

CAS No:
2165325-42-6
Synonyms:
3,​4-​Dimethoxy-​N-​[2-​(1H-​1,​2,​4-​triazol-​1-​yl)​-​5-​(trifluoromethoxy)​phenyl]​-benzamide
Chemical Formula:
Molecular Weight:
408.33
Product Structure
References:
1. Reed et al., 2017. VU6010608, a Novel mGlu7 NAM from a Series of N-(2-(1H-1,2,4-Triazol-1-yl)-5-(trifluoromethoxy)phenyl)benzamides. ACS Med Chem Lett. 8(12):1326-1330.
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