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BV165163
BIO-X

VU 6010608 NEW

This compound is a novel negative allosteric modulator of glutamate metabotropic receptor mGlu7. It is highly selective for mGlu7 over other receptors of mGlu class with IC50 = 795 nM. Although VU 6010608 showed favourable brain penetration in rats, it has been proposed as an in vitro tool for electrophysiology studies. The mGlu7 is broadly distributed within the mammalian central nervous system and it plays a key role in neuronal function and synaptic plasticity.

Technical Data

CAS No: 2165325-42-6
Synonyms: 3,​4-​Dimethoxy-​N-​[2-​(1H-​1,​2,​4-​triazol-​1-​yl)​-​5-​(trifluoromethoxy)​phenyl]​-benzamide
Product Code: BV165163
MDL No: MFCD31693846
Chemical Formula: C18H15F3N4O4
Molecular Weight: 408.33

References


  • Reed et al., 2017. VU6010608, a Novel mGlu7 NAM from a Series of N-(2-(1H-1,2,4-Triazol-1-yl)-5-(trifluoromethoxy)phenyl)benzamides. ACS Med Chem Lett. 8(12):1326-1330.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
2165325-42-6
Synonyms:
3,​4-​Dimethoxy-​N-​[2-​(1H-​1,​2,​4-​triazol-​1-​yl)​-​5-​(trifluoromethoxy)​phenyl]​-benzamide
MDL No:
MFCD31693846
Chemical Formula:
Molecular Weight:
408.33
Product Structure
References:
1. Reed et al., 2017. VU6010608, a Novel mGlu7 NAM from a Series of N-(2-(1H-1,2,4-Triazol-1-yl)-5-(trifluoromethoxy)phenyl)benzamides. ACS Med Chem Lett. 8(12):1326-1330.
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