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BL165041
BIO-X

LSN 3154567 NEW

Nicotinamide phosphoribosyl transferase (NAMPT) competitive inhibitor with IC50 = 3.1 nM. A major consequence of NAMPT inhibition is the attenuation of glycolysis at the GADPH step because this enzyme requires NAD+ for activity. The compound exhibits broad spectrum anti-cancer activity and significant tumor regression was observed in vitro. Although retinal and haematological toxicity has been associated with NAMPT inhibitors, LSN 3154567 does not lead to retinopathy in rats and can be mitigated with co-administration of nicotinic acid.

Technical Data

CAS No: 1698878-14-6
Synonyms: 2-Hydroxy-2-methyl-N-[1,2,3,4-tetrahydro-2-[2-(3-pyridinyloxy)acetyl]-6-isoquinolinyl]-1-propanesulfonamide
Product Code: BL165041
Chemical Formula: C20H25N3O5S
Molecular Weight: 419.50

Literature

References
  • Zhao et al., 2017. Discovery of a Highly Selective NAMPT Inhibitor That Demonstrates Robust Efficacy and Improved Retinal Toxicity with Nicotinic Acid Coadministration. Mol Cancer Ther 16(12):2677-2688.

Solubility

Stability

Datasheets

Specification: View
MSDS: View

LSN 3154567 - Bio-X

CAS No:
1698878-14-6
Synonyms:
2-Hydroxy-2-methyl-N-[1,2,3,4-tetrahydro-2-[2-(3-pyridinyloxy)acetyl]-6-isoquinolinyl]-1-propanesulfonamide
Chemical Formula:
Molecular Weight:
419.50
Product Structure
References:
1. Zhao et al., 2017. Discovery of a Highly Selective NAMPT Inhibitor That Demonstrates Robust Efficacy and Improved Retinal Toxicity with Nicotinic Acid Coadministration. Mol Cancer Ther 16(12):2677-2688.
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