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BP165159

PF 05085727 - Bio-X NEW

Inhibitor of cGMP-dependent phosphodiesterase 2A (PDE2A) with IC50 = 2 nM and has higher affinity over other phosphodiesterases (> 500-fold). Increases cGMP in rodent brain in vivo. Reverses anxiolytic behaviour, enhances performance of new object recognition and social recognition tasks.  Potentiates NMDA signalling and reverses behavioural effects of NMDA antagonists.

Technical Data

CAS No: 1415637-72-7
Product Code: BP165159
Chemical Formula: C20H18F3N7
Molecular Weight: 413.40

References


  • Helal et al., 2017. Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor. J. Med. Chem. 60 (13), 5673–5698.

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PF 05085727 - Bio-X

CAS No:
1415637-72-7
Chemical Formula:
Molecular Weight:
413.40
Product Structure
References:
1. Helal et al., 2017. Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor. J. Med. Chem. 60 (13), 5673–5698.
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