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FB32804
BIO-X

SB 431542

Inhibitor of activin receptor-like kinases (ALK4, ALK5 and ALK7), members of TGFβ type I receptor family. Blocks activin- and TGFβ-mediated signaling and phosphorylation of Smad2 downstream. Suppresses tumor-promoting and tumor-suppressing effects of TGFβ. Promotes differentiation of human embryonic stem cells (hESCs), whilst sustaining mouse ESCs in the undifferentiated state.

Technical Data

CAS No: 301836-41-9
Synonyms: 4-(4-Benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide
Product Code: FB32804
MDL No: MFCD05865244
Chemical Formula: C22H16N4O3
Molecular Weight: 384.39

References


  • Inman GJ et al (2002). SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol Pharmacol 62(1):65-74.
  • Halder SK et al (2005). A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers. Neoplasia 7(5):509-21.
  • Du J et al (2014). Mechanism of SB431542 in inhibiting mouse embryonic stem cell differentiation. Cell Signal 26(10):2107-16.

Solubility

Stability

Further Information


Datasheets


SB 431542 - Bio-X

CAS No:
301836-41-9
Synonyms:
4-(4-Benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide
MDL No:
MFCD05865244
Chemical Formula:
Molecular Weight:
384.39
Product Structure
References:
1. Inman GJ et al (2002). SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol Pharmacol 62(1):65-74.
2. Halder SK et al (2005). A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers. Neoplasia 7(5):509-21.
3. Du J et al (2014). Mechanism of SB431542 in inhibiting mouse embryonic stem cell differentiation. Cell Signal 26(10):2107-16.

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