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FC64978
Antibody

Cetuximab - Buffer solution

A monoclonal antibody against epidermal growth factor receptor (EGFR), inhibiting the binding of endogenous ligands and blocking subsequent receptor activation and intracellularr signalling. Downregulation of EGFR by cetuximab is mediated by inducing receptor internalization for degradation. In cancer, cetuximab has anti-proliferative and anti-angiogenic effects and is studied in colorectal, head and neck, squamous cell and non-small cell lung cancers.

Technical Data

CAS No: 205923-56-4
Product Code: FC64978
MDL No: MFCD06407972
Chemical Formula: C6484H10042N1732O2023S36
Molecular Weight: 145779.95

References


  • Galizia G et al (2007). Cetuximab, a chimeric human mouse anti-epidermal growth factor receptor monoclonal antibody, in the treatment of human colorectal cancer. Oncogene 26(25):3654-60.
  • Guren TK et al (2017). Cetuximab in treatment of metastatic colorectal cancer: final survival analyses and extended RAS data from the NORDIC-VII study. Br J Cancer 116(10): 1271–1278.
  • Concu R and Cordeiro MNDS (2018). Cetuximab and the Head and Neck Squamous Cell Cancer. Curr Top Med Chem 18(3):192-198.

Solubility

Stability

Further Information


Datasheets

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MSDS: View

CAS No:
205923-56-4
MDL No:
MFCD06407972
Chemical Formula:
Molecular Weight:
145779.95
Product Structure
References:
1. Galizia G et al (2007). Cetuximab, a chimeric human mouse anti-epidermal growth factor receptor monoclonal antibody, in the treatment of human colorectal cancer. Oncogene 26(25):3654-60.
2. Guren TK et al (2017). Cetuximab in treatment of metastatic colorectal cancer: final survival analyses and extended RAS data from the NORDIC-VII study. Br J Cancer 116(10): 1271–1278.
3. Concu R and Cordeiro MNDS (2018). Cetuximab and the Head and Neck Squamous Cell Cancer. Curr Top Med Chem 18(3):192-198.
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