Availability
0
Your Basket is Empty
Research & Development
FM23721
BIO-X

GW 501516

Agonist of peroxisome proliferator-activated receptor δ/β (PPARδ/β). The compound activates the nuclear receptor PPARδ downstream signalling and affects hepatic AMPK levels. It boosts the activity of the lipin 1-PPARα-PPARγ coactivator 1 (PGC-1)-α pathway and increases hepatic fatty acid oxidation. It was reported that GW 501516 prevents high-fat diet induced hypertriglyceridemia. 

Technical Data

CAS No: 317318-70-0
Synonyms: GW 501516; 2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]acetic acid
Product Code: FM23721
MDL No: MFCD09033000
Chemical Formula: C21H18F3NO3S2
Molecular Weight: 453.50

References


  • Lee and Chung, 2011. The Role Played by the Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) Activator, GW501516, in Control of Fatty Acid Metabolism: A New Potential Therapeutic Target for Treating Metabolic Syndrome. Endocrinology 152(1):1742–1744.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
317318-70-0
Synonyms:
GW 501516
2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]acetic acid
MDL No:
MFCD09033000
Chemical Formula:
Molecular Weight:
453.50
Product Structure
References:
1. Lee and Chung, 2011. The Role Played by the Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) Activator, GW501516, in Control of Fatty Acid Metabolism: A New Potential Therapeutic Target for Treating Metabolic Syndrome. Endocrinology 152(1):1742–1744.
Click for Specification
Click for MSDS

For requirements greater than the catalogue prepacks email: enquiries@carbosynth.com

Custom Synthesis

For custom synthesis or special requests email: enquiries@carbosynth.com, call +44 (0)1635 578444 or fill out our contact form

Please Wait...