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FB166265
BIO-X

SGC GAK 1 NEW

A potent and selective inhibitor of cyclin G-associated kinase (GAK) with Ki of 3.1 nM. The compound has more than 50-fold selectivity over the closest off-target kinase RIPK2, making it a potent tool for the study of GAK biology. SGC-GAK-1 was tested in vitro in human prostate carcinoma cell lines and showed strong growth inhibition in cell lines with androgen-dependent growth.

Technical Data

CAS No: 2226517-76-4
Synonyms: 6-Bromo-N-(3,4,5-trimethoxyphenyl)-4-quinolinamine
Product Code: FB166265
Chemical Formula: C18H17BrN2O3
Molecular Weight: 389.24

References


  • Asquith et al (2019). SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK). Journal of Medicinal Chemistry 62:2830-2836.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
2226517-76-4
Synonyms:
6-Bromo-N-(3,4,5-trimethoxyphenyl)-4-quinolinamine
Chemical Formula:
Molecular Weight:
389.24
Product Structure
References:
1. Asquith et al (2019). SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK). Journal of Medicinal Chemistry 62:2830-2836.
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