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BB165726

BRD 0705 - Bio-X

A selective GSK3α inhibitor. Induces myeloid differentiation, mediated by changes in morphology and cell surface markers. Disrupts colony formation in AML cells. BRD 0705 does not stabilize β-catenin and thus reduces leukemia-initiating cells (LICs).  

Technical Data

CAS No: 1597440-03-3
Product Code: BB165726
Chemical Formula: C20H23N3O
Molecular Weight: 321.42

References


  • Wagner FF et al (2018). Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med 10(431) pii: eaam8460.

Solubility

Stability

Further Information


Datasheets


BRD 0705 - Bio-X

CAS No:
1597440-03-3
Chemical Formula:
Molecular Weight:
321.42
Product Structure
References:
1. Wagner FF et al (2018). Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med 10(431) pii: eaam8460.

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