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BR165563
BIO-X

RS 127445 hydrochloride NEW

A selective antagonist of serotonin 5-HT2B receptors, inhibiting inositol phosphate formation and calcium release. Blocks 5-HT-induced contraction in rat stomach fundus. Reduces fecal output in vivo, upon inhibition of 5-HT2B by RS 127445, demonstrating a potential role for this receptor in colonic motility. Inhibits visceral hypersensitivity induced by restraint stress or colonic inflammation.

Technical Data

CAS No: 199864-86-3
Product Code: BR165563
Chemical Formula: C17H16FN3·HCl
Molecular Weight: 317.79

References


  • Bonhaus DW et al (1999). RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist. Br J Pharmacol 127(5):1075-82.
  • Bassil AK et al (2009). Inhibition of colonic motility and defecation by RS-127445 suggests an involvement of the 5-HT2B receptor in rodent large bowel physiology. Br J Pharmacol 158(1):252-8.
  • Ohashi-Doi K et al (2010). A selective, high affinity 5-HT 2B receptor antagonist inhibits visceral hypersensitivity in rats. Neurogastroenterol Motil 22(2):e69-76.

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Further Information


Datasheets

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RS 127445 hydrochloride - Bio-X

CAS No:
199864-86-3
Chemical Formula:
Molecular Weight:
317.79
Product Structure
References:
1. Bonhaus DW et al (1999). RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist. Br J Pharmacol 127(5):1075-82.
2. Bassil AK et al (2009). Inhibition of colonic motility and defecation by RS-127445 suggests an involvement of the 5-HT2B receptor in rodent large bowel physiology. Br J Pharmacol 158(1):252-8.
3. Ohashi-Doi K et al (2010). A selective, high affinity 5-HT 2B receptor antagonist inhibits visceral hypersensitivity in rats. Neurogastroenterol Motil 22(2):e69-76.
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