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BL162781
BIO-X

LDN 193189 dihydrochloride

Inhibitor of ALK1, ALK2, ALK3 and ALK6 kinases and bone morphogenetic protein (BMP) pathway. LDN 1931189 is a dorsomorphin derivative that inhibits BMP-mediated activation of Smad, Akt and p38 signalling. LDN 193189 promotes differentiation of human pluripotent cells into PAX6+ anterior neural ectoderm. In combination with basic fibroblast growth factor (FGF2), LDN 193189 promotes differentiation of mouse pluripotent stem cells into inner ear sensory epithelium.

Technical Data

CAS No: 1435934-00-1
Synonyms: 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline 2HCl
Product Code: BL162781
MDL No: MFCD23098917
Chemical Formula: C25H22N6·2HCl
Molecular Weight: 479.40

References


  • Boergermann et al (2010). Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells. The International Journal of Biochemistry and Cell Biology 42(11):1802-1807.
  • Surmacz et al (2012). Directing Differentiation of Human Embryonic Stem Cells Toward Anterior Neural Ectoderm Using Small Molecules. Stem Cells 30:1875–1884.
  • Koehler et al (2013). Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture. Nature 500:217–221.

Solubility

Stability

Further Information


Datasheets

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CAS No:
1435934-00-1
Synonyms:
4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline 2HCl
MDL No:
MFCD23098917
Chemical Formula:
Molecular Weight:
479.40
Product Structure
References:
1. Boergermann et al (2010). Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells. The International Journal of Biochemistry and Cell Biology 42(11):1802-1807.
2. Surmacz et al (2012). Directing Differentiation of Human Embryonic Stem Cells Toward Anterior Neural Ectoderm Using Small Molecules. Stem Cells 30:1875–1884.
3. Koehler et al (2013). Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture. Nature 500:217–221.
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