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BD164375
BIO-X

Docetaxel trihydrate

A cytotoxic taxane and anti-microtubule agent with anti-proliferative activity. Docetaxel binds to the β-subunit of tubulin, which results in increased polymerisation and stabilisation of microtubules. The compound interferes with microtubule dynamics, which leads to the cell cycle arrest in the G2/M phase and apoptosis. The compound has significant inhibitory activity in solid tumors either alone or in combination with other chemotherapeutic agents.

Technical Data

CAS No: 148408-66-6
Product Code: BD164375
MDL No: MFCD26960948
Chemical Formula: C43H53NO14·3(H2O)
Molecular Weight: 861.93

References


  • Clarke and Rivory (2012). Clinical Pharmacokinetics of Docetaxel. Clinical Pharmacokinetics 36(2):99-114.
  • Perez (2009). Microtubule inhibitors: Differentiating tubulin-inhibiting agents based on mechanisms of action, clinical activity, and resistance. Molecular Cancer Therapy 8(8):2086–95.

Solubility

Stability

Further Information


Datasheets


CAS No:
148408-66-6
MDL No:
MFCD26960948
Chemical Formula:
Molecular Weight:
861.93
Product Structure
References:
1. Clarke and Rivory (2012). Clinical Pharmacokinetics of Docetaxel. Clinical Pharmacokinetics 36(2):99-114.
2. Perez (2009). Microtubule inhibitors: Differentiating tubulin-inhibiting agents based on mechanisms of action, clinical activity, and resistance. Molecular Cancer Therapy 8(8):2086–95.

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