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BP162743
BIO-X

PX 866

Potent and irreversible inhibitor of phosphoinositide-3-kinase (PtdIns-3-kinase) with IC50 of 0.1 nM. PX 866 inhibited cell motility and growth of 3D spheroids of glioblastoma, breast, prostate and colon cancer cell lines at low nanomolar concentrations. PX 866 also exhibited anti-tumoral activity in vivo in xenograft models for ovarian and lung cancer.

Technical Data

CAS No: 502632-66-8
Product Code: BP162743
MDL No: MFCD11840616
Chemical Formula: C29H35NO8
Molecular Weight: 525.59

References


  • Ihle et al (2004). Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signalling. Molecular Cancer Therapeutics 3(7):763-772.
  • Howes et al (2007). The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures. Molecular Cancer Therapeutics 6(9):2505-2514.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
502632-66-8
MDL No:
MFCD11840616
Chemical Formula:
Molecular Weight:
525.59
Product Structure
References:
1. Ihle et al (2004). Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signalling. Molecular Cancer Therapeutics 3(7):763-772.
2. Howes et al (2007). The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures. Molecular Cancer Therapeutics 6(9):2505-2514.
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