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FA145491
BIO-X

AG 120

Inhibits isocitrate dehydrogenase 1 (IDH-1) harbouring a gain of function mutation at R132, which causes impaired cellular differentiation via epigenetic modulation. By inhibiting mutant IDH1, synthesis of oncometabolite 2-hydroxyglutarate is reduced. This compound therefore has therapeutic potential in solid and haematological malignancies, such as acute myeloid leukemia (AML). 

Technical Data

CAS No: 1448347-49-6
Synonyms: Ivosidenib
Product Code: FA145491
MDL No: MFCD29036964
Chemical Formula: C28H22ClF3N6O3
Molecular Weight: 582.96

References


  • Fan B et al (2015). Longitudinal Pharmacokinetic/Pharmacodynamic Profile of AG-120, a Potent Inhibitor of the IDH1 Mutant Protein, in a Phase 1 Study of IDH1-Mutant Advanced Hematologic Malignancies. Blood 126(23): 1310.
  • DiNardo CD et al (2018). Ivosidenib (AG-120) in Mutant IDH1 AML and Advanced Hematologic Malignancies: Results of a Phase 1 Dose Escalation and Expansion Study. Blood 130:725.
  • Popovici-Muller J et al (2018). Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers. ACS Med Chem Lett 9(4):300-305.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

AG 120 - Bio-X

CAS No:
1448347-49-6
Synonyms:
Ivosidenib
MDL No:
MFCD29036964
Chemical Formula:
Molecular Weight:
582.96
Product Structure
References:
1. Fan B et al (2015). Longitudinal Pharmacokinetic/Pharmacodynamic Profile of AG-120, a Potent Inhibitor of the IDH1 Mutant Protein, in a Phase 1 Study of IDH1-Mutant Advanced Hematologic Malignancies. Blood 126(23): 1310.
2. DiNardo CD et al (2018). Ivosidenib (AG-120) in Mutant IDH1 AML and Advanced Hematologic Malignancies: Results of a Phase 1 Dose Escalation and Expansion Study. Blood 130:725.
3. Popovici-Muller J et al (2018). Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers. ACS Med Chem Lett 9(4):300-305.
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