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BD167529
BIO-X

DO 264

Inhibits lysophosphatidylserine hydrolysis by the integral membrane serine hydrolase ABHD12 (IC50 = 1.3 µM). Raised levels of lysophosphatidylserine were observed in mouse brain in vivo and in primary human macrophages. DO 264 had proinflammatory effects, following infection with lymphocytic choriomeningitis virus (LCV) clone 13 in mice, resulting in severe inflammatory lung damage.

Technical Data

Synonyms: DO264
Product Code: BD167529
Chemical Formula: C23H20Cl2F3N5O2S
Molecular Weight: 558.40

References


  • Ogasawara D et al (2018). Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo. Nat Chem Biol 14(12):1099-1108.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

Synonyms:
DO264
Chemical Formula:
Molecular Weight:
558.40
Product Structure
References:
1. Ogasawara D et al (2018). Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo. Nat Chem Biol 14(12):1099-1108.
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