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BB165666

BL 918 - Bio-X NEW

A potent small-molecule activator of UNC-51-like kinase 1 (ULK1), a serine-threonine kinase involved in autophagy. Promotes cytoprotective autophagy in MPP+-treated SH-SY5Y cells, via the ULK complex. Improves motor dysfunction and reduces loss of dopaminergic neurons, mediated by MPTP, in in vivo models of Parkinson’s disease.

Technical Data

CAS No: 2101517-69-3
Product Code: BB165666
Chemical Formula: C23H15F8N3OS
Molecular Weight: 533.44

Literature


  • Ouyang L et al (2018). Small-Molecule Activator of UNC-51-Like Kinase 1 (ULK1) That Induces Cytoprotective Autophagy for Parkinson's Disease Treatment. J Med Chem 61(7):2776-2792.

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Stability

Further Information


Datasheets

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MSDS: View

BL 918 - Bio-X

CAS No:
2101517-69-3
Chemical Formula:
Molecular Weight:
533.44
Product Structure
References:
1. Ouyang L et al (2018). Small-Molecule Activator of UNC-51-Like Kinase 1 (ULK1) That Induces Cytoprotective Autophagy for Parkinson's Disease Treatment. J Med Chem 61(7):2776-2792.
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