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BA17966

ACEA

Cannabinoid type 1 (CB1) receptor agonist. Anti-depressant activity demonstrated in vivo alone, as well as enhancing the effect of fluoxetine. In the brain, ACEA activates CB1 receptors expressed in the mitochondria of neuronal cells to elicit neuroprotective effects. This is mediated by inducing glycogen synthase kinase-3β (GSK-3β) phosphorylation and inhibiting the opening of mitochondrial permeability transition pore (MPTP).

Technical Data

CAS No: 220556-69-4
Synonyms: (5Z,8Z,11Z,14Z)-N-(2-Chloroethyl)-5,8,11,14-eicosatetraenamide; Arachidonyl-2-chloroethylamide
Product Code: BA17966
MDL No: MFCD02683581
Chemical Formula: C22H36ClNO
Molecular Weight: 365.98

References


  • Rutkowska M and Jachimczuk O (2004). Antidepressant--like properties of ACEA (arachidonyl-2-chloroethylamide), the selective agonist of CB1 receptors. Acta Pol Pharm 61(2):165-7.
  • Bai F et al (2017). Arachidonyl-2-Chloroethylamide Alleviates Cerebral Ischemia Injury Through Glycogen Synthase Kinase-3β-Mediated Mitochondrial Biogenesis and Functional Improvement. Mol Neurobiol 54(2):1240-1253.
  • Ma L et al (2018). Inhibition of mitochondrial permeability transition pore opening contributes to cannabinoid type 1 receptor agonist ACEA-induced neuroprotection. Neuropharmacology 135:211-222.

Solubility

Stability

Further Information


Datasheets


ACEA

CAS No:
220556-69-4
Synonyms:
(5Z,8Z,11Z,14Z)-N-(2-Chloroethyl)-5,8,11,14-eicosatetraenamide
Arachidonyl-2-chloroethylamide
MDL No:
MFCD02683581
Chemical Formula:
Molecular Weight:
365.98
Product Structure
References:
1. Rutkowska M and Jachimczuk O (2004). Antidepressant--like properties of ACEA (arachidonyl-2-chloroethylamide), the selective agonist of CB1 receptors. Acta Pol Pharm 61(2):165-7.
2. Bai F et al (2017). Arachidonyl-2-Chloroethylamide Alleviates Cerebral Ischemia Injury Through Glycogen Synthase Kinase-3β-Mediated Mitochondrial Biogenesis and Functional Improvement. Mol Neurobiol 54(2):1240-1253.
3. Ma L et al (2018). Inhibition of mitochondrial permeability transition pore opening contributes to cannabinoid type 1 receptor agonist ACEA-induced neuroprotection. Neuropharmacology 135:211-222.

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